Perioral dermatitis - 口周皮炎https://en.wikipedia.org/wiki/Perioral_dermatitis
口周皮炎 (Perioral dermatitis) 是面部常见的皮疹。症状包括多个直径 1–2 毫米的小肿块或水疱,常伴有局部发红和鳞屑。病变仅局限于口唇和鼻孔周围的皮肤,可呈持续性或复发性,临床上常与酒渣鼻、痤疮及过敏性皮炎相似。

外用类固醇、保湿霜和化妆品均可能诱发此病。治疗原则是停用外用类固醇和化妆品,症状较重者可口服四环素。停用类固醇初期可能会出现皮疹加重。

据估计,发达国家每年约有 0.5–1% 的人患此病,其中高达 90% 的患者为 16–45 岁的女性。

治疗 - 非处方药
口周皮炎常由化妆品引起的慢性接触性皮炎导致,建议避免在口周使用化妆品。可尝试服用非处方抗组胺药,疗程通常需数月。
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  • 口腔和鼻孔周围出现丘疹,伴有红色背景,常表现为口腔周围的斑块或脓疱。
    References Perioral Dermatitis 30247843 
    NIH
    Perioral dermatitis 是一种常见于年轻女性的良性皮肤病,特征是口腔周围出现红色小丘疹或干燥、鳞屑。虽然主要累及口周,但有时也可波及眼周和鼻旁,故称“口周皮炎”。使用局部类固醇可诱发或加重该病,因而治疗的第一步通常是停用这些类固醇。其他治疗方案包括局部使用甲硝唑或钙调神经磷酸酶抑制剂,亦可口服四环素类抗生素。口周皮炎大多数对治疗反应良好,但有时会顽固或反复发作。
    Perioral dermatitis is a benign eruption that occurs most commonly in young, female adults, consisting of small inflammatory papules and pustules or pink, scaly patches around the mouth. Although the perioral region is the most common area of distribution, this disease also can affect the periocular and paranasal skin. For this reason, it is often referred to as periorificial dermatitis. Topical steroid use to the face can trigger this, and therefore, a primary recommendation for treatment would be discontinuation of steroid application by the patient. Other treatment approaches include topical metronidazole, topical calcineurin inhibitors, and oral tetracycline antibiotics. Perioral dermatitis often responds readily to therapy but can be chronic and recurrent.
     Allergic contact cheilitis caused by propolis: case report 35195191 
    NIH
    蜂胶是蜜蜂从植物中提取的亲脂性物质。本病例报告旨在展示该物质在过敏性接触性唇炎中的重要致病作用。一名21岁女性患者主诉口周部位出现瘙痒性湿疹,已持续5年。近几个月,病变亦波及颈部。诊断为接触性皮炎后,她接受了斑贴试验。结果显示蜂胶呈强阳性(++)。
    Propolis is a lipophilic resin extracted from plants by bees. The purpose of this case report was to show the importance of this substance as cause of allergic contact cheilitis. A 21-year-old female patient complained of pruritic perioral eczema for 5 years. In the past months it also affected the neck. After diagnosing contact dermatitis, she was submitted to a patch test with a Latin American baseline series. The result was strongly positive for propolis (++)
     Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face 33911757 
    NIH
    以红斑丘疹为特征的各种炎症性皮肤病。临床常见病——folliculitis和rosacea;相对罕见的疾病——eosinophilic pustular folliculitis (EPF)、granulomatous periorificial dermatitis (GPD)和lupus miliaris disseminatus faciei (LMDF)。
    Various inflammatory skin diseases characterized by erythematous papules that most often affect the face include clinically common folliculitis and rosacea, and relatively rare eosinophilic pustular folliculitis (EPF), granulomatous periorificial dermatitis (GPD), and lupus miliaris disseminatus faciei (LMDF).